ChloroquineV1, Main, Exploration, bibRecord, 002546

Fibroblast Growth Factors Are Translocated to the Nucleus of Human Endothelial Cells in a Microtubule- and Lysosome-Independent Pathway

Identifieur interne : 002546 ( Main/Exploration ); précédent : 002545; suivant : 002547

Fibroblast Growth Factors Are Translocated to the Nucleus of Human Endothelial Cells in a Microtubule- and Lysosome-Independent Pathway

Auteurs : Guo-Fu Hu ; Hyun-Ju Kim ; Chi-Jie Xu ; James F. Riordan

Source :

Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2000.

RBID : ISTEX:712670CFC1AC36FDDB3C8F73B9399B5F3EF73410

English descriptors

Teeft :
- Acad, Afgf, Angiogenic, Angiogenic factors, Angiogenic proteins, Angiogenin, Bfgf, Biochem, Biol, Biophysical research communications, Broblast, Broblast growth factor, Broblast growth factors, Cell biol, Cell nucleus, Cell proliferation, Chloroquine, Cytosol, Cytosolic, Cytosolic accumulation, Estradiol, Fgfs, Fusion protein, Growth factor, Growth factors, Human umbilical artery, Human umbilical vein, Huve, Huve cells, Leupeptin, Lysosomal, Lysosomal inhibitors, Lysosomal processing, Microtubule, Microtubule network, Natl, Nuclear translocation, Plasma membrane, Proc, Receptor, Subcellular, Subcellular distribution, Subcellular fraction, Translocation, Umbilical.

Abstract

Abstract: Exogenous acidic and basic fibroblast growth factors undergo rapid nuclear translocation in human umbilical vein endothelial cells. When nuclear translocation reaches saturation, more than 70% of the internalized growth factors are in the nuclear fraction. Lysosomal inhibitors, such as leupeptin and chloroquine, and microtubule inhibitors including colchicine and 2-methoxyl-β-estradiol neither increase nor decrease nuclear translocation. The results suggest that nuclear translocation of fibroblast growth factors does not require cytosolic accumulation or lysosomal processing and that the transportation of exogenous growth factors across the cytoplasm is independent of microtubules.

Url:

https://api.istex.fr/ark:/67375/6H6-XXTVP0BV-9/fulltext.pdf

DOI: 10.1006/bbrc.2000.2978

Affiliations:

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Le document en format XML

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<author><name sortKey="Xu, Chi Jie" sort="Xu, Chi Jie" uniqKey="Xu C" first="Chi-Jie" last="Xu">Chi-Jie Xu</name>
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<term>Angiogenin</term>
<term>Bfgf</term>
<term>Biochem</term>
<term>Biol</term>
<term>Biophysical research communications</term>
<term>Broblast</term>
<term>Broblast growth factor</term>
<term>Broblast growth factors</term>
<term>Cell biol</term>
<term>Cell nucleus</term>
<term>Cell proliferation</term>
<term>Chloroquine</term>
<term>Cytosol</term>
<term>Cytosolic</term>
<term>Cytosolic accumulation</term>
<term>Estradiol</term>
<term>Fgfs</term>
<term>Fusion protein</term>
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<term>Growth factors</term>
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<term>Human umbilical vein</term>
<term>Huve</term>
<term>Huve cells</term>
<term>Leupeptin</term>
<term>Lysosomal</term>
<term>Lysosomal inhibitors</term>
<term>Lysosomal processing</term>
<term>Microtubule</term>
<term>Microtubule network</term>
<term>Natl</term>
<term>Nuclear translocation</term>
<term>Plasma membrane</term>
<term>Proc</term>
<term>Receptor</term>
<term>Subcellular</term>
<term>Subcellular distribution</term>
<term>Subcellular fraction</term>
<term>Translocation</term>
<term>Umbilical</term>
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<front><div type="abstract" xml:lang="en">Abstract: Exogenous acidic and basic fibroblast growth factors undergo rapid nuclear translocation in human umbilical vein endothelial cells. When nuclear translocation reaches saturation, more than 70% of the internalized growth factors are in the nuclear fraction. Lysosomal inhibitors, such as leupeptin and chloroquine, and microtubule inhibitors including colchicine and 2-methoxyl-β-estradiol neither increase nor decrease nuclear translocation. The results suggest that nuclear translocation of fibroblast growth factors does not require cytosolic accumulation or lysosomal processing and that the transportation of exogenous growth factors across the cytoplasm is independent of microtubules.</div>
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<tree><noCountry><name sortKey="Hu, Guo Fu" sort="Hu, Guo Fu" uniqKey="Hu G" first="Guo-Fu" last="Hu">Guo-Fu Hu</name>
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<name sortKey="Riordan, James F" sort="Riordan, James F" uniqKey="Riordan J" first="James F." last="Riordan">James F. Riordan</name>
<name sortKey="Xu, Chi Jie" sort="Xu, Chi Jie" uniqKey="Xu C" first="Chi-Jie" last="Xu">Chi-Jie Xu</name>
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Fibroblast Growth Factors Are Translocated to the Nucleus of Human Endothelial Cells in a Microtubule- and Lysosome-Independent Pathway

Fibroblast Growth Factors Are Translocated to the Nucleus of Human Endothelial Cells in a Microtubule- and Lysosome-Independent Pathway

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri